Abstract: Disaster resilience is gaining increasing attention from both industry and academia, but difficulties in operationalizing the concept remain, especially in the urban context. Currently, there is scant literature on measuring both spatial and temporal aspects of resilience empirically. We propose a bio-inspired quantitative framework to track urban resilience to disasters. This framework was built upon a daily human mobility network, which was generated by geolocations from a Twitter Streaming API. System-wide metrics were computed over time (i.e. pre-, during and post-disasters). Fisher information was further adopted to detect the perturbation and dynamics in the system. Specifically, we applied the proposed approach in a flood case in the metropolis of São Paulo. The proposed approach is efficient in uncovering the dynamics in human movements and the underlying spatial structure. It adds to our understanding of the resilience process in urban disasters.