Abstract: This paper develops a set of design considerations for information systems to support the management of interdependent critical infrastructure systems. Constraints on how these systems are managed are oriented along technical, political and organizational dimensions, though objectives along these dimensions may conflict and thus be difficult to satisfy. This paper harnesses methodologies from software engineering and cognitive science in order to specify opportunities for using information systems to support human-centered management of critical infrastructure systems. The particular focus of this work is on developing information systems to support visualization and visual problem solving. Progress to date is discussed in terms of an ongoing research project which uses as a test-bed data associated with lower Manhattan (New York, USA).