Abstract: Intentional threats including terrorism have become a worldwide catastrophe risk since recent years. To protect the cities from being attacked, the macro-level study of decision analysis should be given more considerations. In this paper, we proposed a model for describing the strategic game between attackers and defenders based on the methodology of matrix game. This model can be employed to determine which target will be selected by attackers and which attacking strategy and defending strategy will be chosen by attackers and defenders respectively. Furthermore, the defenders of the city can use this model to set priorities among their defending strategies. The importance of this work is to establish a reasonable framework for modeling the attacking and defending strategies rather than assessing the real risk of urban targets, so the model is illustrated by using fictitious numbers. The model proposed in this paper can provide scientific basis for macroscopic decision making in responding to intentional threats. © 2012 ISCRAM.