Abstract: Crisis response is, as any other collaborative networked organization, challenged by changes and vulnerabilities. Moreover, as a complex system with distributed activities and numerous interdependencies, considering the risk of such an organization at a systemic level, including time and space dimensions, is necessary. Systemic risk management is a topic traditionally studied in the finance area. Even if a few researches now focus on the supply chain management area (a more relatable domain regarding crisis response), there is even fewer literature regarding systemic risk management for the crisis response. Thus, this paper proposes first to define systemic risk related to the case of the crisis response. Then, a framework for context-aware systemic risk management is presented, to support the design as well as the follow-up of the crisis response, meeting one of the challenges of the Sendai Framework for Disaster Risk Reduction.