Abstract: Quality and timely knowledge is critical to effective humanitarian operations during crises. Despite this, there remain limitations to its capture, exchange and understanding both in the inter and intra agency settings. To improve this, methods like interoperability should be improved within humanitarian aid organizations and their wider networks. Learning from the experiences and insights of domestic and international delegates of the Canadian Red Cross, this paper highlights that the biggest added values of interoperability to the intra-agency setting are (i.) increasing organizational capacity, expertise and reputation, (ii.) better tools, processes and leveraging valuable knowledge, and (iii.) improved engagement of volunteers, employees and delegates. The most prevalent barriers are (i.) workplace culture, (ii.) differences in operations, context and communications and (iii.) the socio-technical barriers of systems, processes and integration. The paper concludes by presenting lessons for humanitarian organizations to improve interoperability, supporting resilient responses for future crisis management.