Abstract: In case of a mass-casualty incident, e.g. due to a disaster, a high number of patients need medical care within a short time frame and often, a significant percentage must be transported to a hospital or another suitable care facility. Then, different mass transportation modes (e.g., busses, ships or trains) may be used to quickly transport patients to available medical treatment centres outside of the disaster area. Within the SimPaTrans project, we develop a simulation-based decision support system for locating, sizing and analysing different modes of transport in order to prepare for mass-casualty incidents in Germany. In this paper, we present the outline of the tool as well as a first optimisation use case for transportation patients within the city of Karlsruhe, Germany